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Evaluation of the validity and utility of a transdiagnostic psychosis dimension encompassing schizophrenia and bipolar disorder

Reininghaus, U; Bohnke, J.R; Hosang, Georgina M.; Farmer, Anne E.; Burns, T; McGuffin, Peter and Bentall, R.P. 2015. Evaluation of the validity and utility of a transdiagnostic psychosis dimension encompassing schizophrenia and bipolar disorder. The British Journal of Psychiatry, 209, pp. 107-113. ISSN 0007-1250 [Article]

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Abstract or Description

Background

In recent years, the Kraepelinian dichotomy has been challenged in light of evidence on shared genetic and environmental factors for schizophrenia and bipolar disorder, but empirical efforts to identify a transdiagnostic phenotype of psychosis remain remarkably limited.

Aims

To investigate whether schizophrenia spectrum and bipolar disorder lie on a transdiagnostic spectrum with overlapping non-affective and affective psychotic symptoms.

Method

Multidimensional item-response modelling was conducted on symptom ratings of the OPerational CRITeria (OPCRIT) system in 1168 patients with schizophrenia spectrum and bipolar disorder.

Results

A bifactor model with one general, transdiagnostic psychosis dimension underlying affective and non-affective psychotic symptoms and five specific dimensions of positive, negative, disorganised, manic and depressive symptoms provided the best model fit and diagnostic utility for categorical classification.

Conclusions

Our findings provide support for including dimensional approaches into classification systems and a directly measurable clinical phenotype for cross-disorder investigations into shared genetic and environmental factors of psychosis.

Item Type:

Article

Identification Number (DOI):

https://doi.org/10.1192/bjp.bp.115.167882

Additional Information:

The title of the AAM changed upon acceptance.

Departments, Centres and Research Units:

Psychology

Dates:

DateEvent
19 September 2015Accepted

Item ID:

19463

Date Deposited:

18 Jan 2017 12:44

Last Modified:

09 Jul 2018 14:11

Peer Reviewed:

Yes, this version has been peer-reviewed.

URI:

http://research.gold.ac.uk/id/eprint/19463

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