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Diffusion tensor imaging detects age related white matter change over a 2 year follow-up which is associated with working memory decline.

Charlton, Rebecca A; Schiavone, F; Barrick, T R; Morris, R G and Markus, H S. 2010. Diffusion tensor imaging detects age related white matter change over a 2 year follow-up which is associated with working memory decline. Journal of Neurology, Neurosurgery, and Psychiatry, 81(1), pp. 13-19. ISSN 0022-3050 [Article]

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Abstract or Description

Background: Diffusion tensor imaging (DTI) is a sensitive method for detecting white matter damage, and in cross sectional studies DTI measures correlate with age related cognitive decline. However, there are few data on whether DTI can detect age related changes over short time periods and whether such change correlates with cognitive function.

Methods: In a community sample of 84 middle-aged and elderly adults, MRI and cognitive testing were performed at baseline and after 2 years. Changes in DTI white matter histograms, white matter hyperintensity (WMH) volume and brain volume were determined. Change over time in performance on tests of executive function, working memory and information processing speed were also assessed.

Results: Significant change in all MRI measures was detected. For cognition, change was detected for working memory and this correlated with change in DTI only. In a stepwise regression, with change in working memory as the dependent variable, a DTI histogram measure explained 10.8% of the variance in working memory. Change in WMH or brain volume did not contribute to the model.

Conclusions: DTI is sensitive to age related change in white matter ultrastructure and appears useful for monitoring age related white matter change even over short time periods.

Item Type:

Article

Identification Number (DOI):

https://doi.org/10.1136/jnnp.2008.167288

Departments, Centres and Research Units:

Psychology
Research Office > REF2014

Dates:

DateEvent
January 2010Published

Item ID:

8321

Date Deposited:

09 Jun 2013 12:45

Last Modified:

30 Jun 2017 14:11

Peer Reviewed:

Yes, this version has been peer-reviewed.

URI:

http://research.gold.ac.uk/id/eprint/8321

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