Understanding cell lineages as complex adaptive systems

d'Inverno, Mark and Theise, Neil. 2004. Understanding cell lineages as complex adaptive systems. Blood Cells Molecules and Diseases, 32(1), pp. 17-20. ISSN 1079-9796 [Article]

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Abstract or Description

Stem cells may be considered complex reactive systems because of their vast number in a living system, their reactive nature, and the
influence of local environmental factors (such as the state of neighboring cells, tissue matrix, stem cell physiological processes) on their
behavior. In such systems, emergent global behavior arises through the multitude of local interactions among the cell agents. Approaching
hematopoietic and other stem cell lineages from this perspective have critical ramifications on current thinking relating to the plasticity of
these lineage systems, the modeling of stem cell systems, and the interpretation of clinical data regarding many diseases within such models

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January 2004Published

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Date Deposited:

12 Mar 2009 15:41

Last Modified:

20 Jun 2017 09:59

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Yes, this version has been peer-reviewed.



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