Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

Jelenkovic, Aline; et al., et al., and Gregory, Alice M.. 2016. Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts. Scientific Reports, 6, p. 28496. ISSN 2045-2322 [Article]

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Abstract or Description

Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

Item Type:

Article

Identification Number (DOI):

https://doi.org/10.1038/srep28496

Departments, Centres and Research Units:

Psychology

Dates:

DateEvent
2 June 2016Accepted
23 June 2016Published

Item ID:

18631

Date Deposited:

23 Jun 2016 13:21

Last Modified:

14 Apr 2021 14:37

Peer Reviewed:

Yes, this version has been peer-reviewed.

URI:

https://research.gold.ac.uk/id/eprint/18631

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