Hair Trace Element and Electrolyte Content in Women with Natural and In Vitro Fertilization-Induced Pregnancy

Skalny, Anatoly V.; Tinkov, Alexey A.; Voronina, Irina; Terekhina, Olga; Skalnaya, Margarita G. and Kovas, Yulia. 2018. Hair Trace Element and Electrolyte Content in Women with Natural and In Vitro Fertilization-Induced Pregnancy. Biological Trace Element Research, 181(1), pp. 1-9. ISSN 0163-4984 [Article]

BTER_Kovas_proof.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (203kB) | Preview

Abstract or Description

The objective of the present study was to perform comparative analysis of hair trace element content in women with natural and in vitro fertilization (IVF)-induced pregnancy. Hair trace element content in 33 women with IVF-induced pregnancy and 99 age- and body mass index-matched control pregnant women (natural pregnancy) was assessed using inductively coupled plasma mass spectrometry. The results demonstrated that IVF-pregnant women are characterized by significantly lower hair levels of Cu, Fe, Si, Zn, Ca, Mg, and Ba at p < 0.05 or lower. Comparison of the individual levels with the national reference values demonstrated higher incidence of Fe and Cu deficiency in IVF-pregnant women in comparison to that of the controls. IVF pregnancy was also associated with higher hair As levels (p < 0.05). Multiple regression analysis revealed a significant interrelation between IVF pregnancy and hair Cu, Fe, Si, and As content. Hair Cu levels were also influenced by vitamin/mineral supplementation and the number of pregnancies, whereas hair Zn content was dependent on prepregnancy anthropometric parameters. In turn, planning of pregnancy had a significant impact on Mg levels in scalp hair. Generally, the obtained data demonstrate an elevated risk of copper, iron, zinc, calcium, and magnesium deficiency and arsenic overload in women with IVF-induced pregnancy. The obtained data indicate the necessity of regular monitoring of micronutrient status in IVF-pregnant women in order to prevent potential deleterious effects of altered mineral homeostasis.

Item Type:


Identification Number (DOI):


In vitro fertilization, Iron, Copper, Deficiency, Arsenic

Departments, Centres and Research Units:



January 2018Published
25 April 2017Published Online
20 April 2017Accepted

Item ID:


Date Deposited:

05 Sep 2017 15:43

Last Modified:

14 Apr 2021 11:07

Peer Reviewed:

Yes, this version has been peer-reviewed.


View statistics for this item...

Edit Record Edit Record (login required)