Genetic and Environmental Etiology of Nicotine Use in Sri Lankan Male Twins.

Zavos, H.M.S.; Kovas, Yulia; Ball, H.A.; Ball, D.; Siribaddana, S.H.; Glozier, N.; Sumathipala, A.; McGuffin, P.; Hotopf, H. and Rijsdijk, F.. 2012. Genetic and Environmental Etiology of Nicotine Use in Sri Lankan Male Twins. Behavior Genetics, 42(5), pp. 798-807. ISSN 0001-8244 [Article]

[img] Text
SL Twin Study Smoking _BG Resubmission_R2.docx - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (149kB)

Abstract or Description

Little is known about the prevalence and etiology of tobacco use in Asian populations. This study aims to test whether the finding of substantial heritability for tobacco-related phenotypes in Western populations is generalizable to developing countries. The twin method was used to estimate the relative contribution of genetic and environmental influences on nicotine-related phenotypes. Participants were selected from the population based Sri Lankan Twin Registry. The Composite International Diagnostic Interview was administered to 1804 male individuals to assess five phenotypes: nicotine use; desire and unsuccessful attempts to quit smoking; subjective feeling of being tobacco dependent; and two DSM-IV diagnoses; nicotine dependence and nicotine withdrawal. Almost one third of the male twins were life-time smokers. The genetic results were consistent with the previously reported findings from Western and Chinese populations, in that the nicotine use traits were significantly heritable, with environmental influences being of the non-shared nature. The results derived from the Causal Contingent Common pathway model (CCC) supported previous findings that show that liabilities to regular smoking and subsequent problem smoking have both shared and specific genetic influences.

Item Type:


Identification Number (DOI):


Twin method, Nicotine use, Heritability, Environmental effects, CIDI, Causal Contingent Common Pathway Model (CCC)

Departments, Centres and Research Units:



September 2012Published
19 May 2012Published Online
25 April 2012Accepted

Item ID:


Date Deposited:

13 Jul 2017 14:26

Last Modified:

28 Jun 2021 10:52

Peer Reviewed:

Yes, this version has been peer-reviewed.


View statistics for this item...

Edit Record Edit Record (login required)