Mnemonic function in small vessel disease and associations with white matter tract microstructure

Metoki, A; Brookes, R.L.; Zeestraten, E.; Lawrence, A.J.; Morris, R.G.; Barrick, Thomas R; Markus, Hugh S and Charlton, Rebecca A. 2017. Mnemonic function in small vessel disease and associations with white matter tract microstructure. Neuropsychologia, 104, pp. 1-7. ISSN 0028-3932 [Article]

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Abstract or Description

Cerebral small vessel disease (SVD) is associated with deficits in working memory, with a relative sparing of long-term memory; function may be influenced by white matter microstructure. Working and long-term memory were examined in 106 patients with SVD and 35 healthy controls. Microstructure was measured in the uncinate fasciculi and cingula. Working memory was more impaired than long-term memory in SVD, but both abilities were reduced compared to controls. Regression analyses found that having SVD explained the variance in memory functions, with additional variance explained by the cingula (working memory) and uncinate (long-term memory). Performance can be explained in terms of integrity loss in specific white matter tract associated with mnemonic functions.

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Funding: The SCANS research study was supported by a Wellcome Trust grant (081589). Recruitment was supported by the English National Institute of Health Research (NIHR) Clinical Stroke Research Network. Hugh Markus is supported by an NIHR Senior Investigator award and his work is supported by the Cambridge University Hospital Comprehensive NIHR Biomedical Research Unit. Andrew Lawrence is supported by a project grant from Alzheimer's Research UK (ARUK-PG2013-2). The GENIE study was supported by Research into Ageing (UK) awards (227, HSM: 259, TRB).


Long-term memory; Working memory; Cingulum; Uncinate; Ageing; Small vessel disease

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23 July 2017Accepted
24 July 2017Published Online
1 September 2017Published

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Date Deposited:

07 Aug 2017 10:48

Last Modified:

29 Apr 2020 16:29

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Yes, this version has been peer-reviewed.


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