Accelerated forgetting in healthy older samples: Implications for methodology, future ageing studies, and early identification of risk of dementia

McGibbon, Terence; Jansari, Ashok S.; Demirjian, Jessica; Nemes, Ana and Opre, Adrian. 2022. Accelerated forgetting in healthy older samples: Implications for methodology, future ageing studies, and early identification of risk of dementia. Quarterly Journal of Experimental Psychology, ISSN 1747-0218 [Article] (In Press)

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Abstract or Description

Accelerated long-term forgetting (ALF) has been reported in healthy older individuals, and is a possible early marker for risk of developing Alzheimer’s disease (AD). The Verbal Associative Learning & Memory Test (VALMT; McGibbon & Jansari, 2013) addresses methodological weaknesses in existing clinical tests and has detected ALF in epilepsy within an hour. We used VALMT to investigate learning and forgetting in healthy older participants. Older (60-69yrs) and Younger (19-31yrs) participants were compared. Using VALMT, unrelated word-pairs were learnt to criterion, then cued-recall tested at delays of 5, 30 and 55 minutes. Unique pairs were tested at each delay. Subjective memory complaints data was gathered, and the Wechsler Memory Scale Logical Memory test (WMS-LM; a standard clinical measure) was administered. VALMT identified a significant difference in delayed recall between Younger and Older groups by 55 minutes (d = 1.32). While ‘fast-learning’ Older participants scored similarly to Younger participants, ‘slow-learning’ Older participants were impaired at all delays. Forgetting rates suggested degradation of memory starts during early synaptic consolidation rather than later system-level consolidation. Increased subjective memory complaints were associated with reduced VALMT scores. By contrast, WMS-LM failed to identify significant differences between any groups, and did not correlate with memory complaints. We conclude VALMT may be better able than WMS-LM to identify subtle impairments in healthy older adults within a single clinical visit, and VALMT results better reflect subjective experience. Older slow-learners forget faster and report more subjective memory complaints, which may indicate a group at risk of developing AD.

Item Type:

Article

Identification Number (DOI):

https://doi.org/10.1177/17470218221113412

Additional Information:

Supplementary material: The supplementary material is available at qjep.sagepub.com.

Keywords:

Accelerated long-term forgetting; accelerated forgetting; ageing; forgetting rates; consolidation

Departments, Centres and Research Units:

Psychology

Dates:

DateEvent
14 June 2022Accepted
2 July 2022Published Online

Item ID:

32380

Date Deposited:

08 Nov 2022 11:30

Last Modified:

08 Nov 2022 12:36

Peer Reviewed:

Yes, this version has been peer-reviewed.

URI:

https://research.gold.ac.uk/id/eprint/32380

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