Japanese Translation and Validation of Genomic Knowledge Measure in the International Genetics Literacy and Attitudes Survey (iGLAS-GK)

Yoshida, Akiko; Tokutomi, Tomoharu; Fukushima, Akimune; Chapman, Robert; Selita, Fatos; Kovas, Yulia and Sasaki, Makoto. 2023. Japanese Translation and Validation of Genomic Knowledge Measure in the International Genetics Literacy and Attitudes Survey (iGLAS-GK). Genes, 14(4), 814. ISSN 2073-4425 [Article]

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Abstract or Description

Knowledge of genetics is essential for understanding the results of genetic testing and its implications. Recent advances in genomic research have allowed us to predict the risk of onset of common diseases based on individual genomic information. It is anticipated that more people will receive such estimates of risks based on their genomic data. However, currently, there is no measure for genetic knowledge that includes post-genome sequencing advancements in Japan. In this study, we translated the genomic knowledge measure in the International Genetics Literacy and Attitudes Survey (iGLAS-GK) into Japanese and validated it in a general Japanese adult population (n = 463). The mean score was 8.41 (SD 2.56, range 3–17). The skewness and kurtosis were 0.534 and 0.088, respectively, and the distribution showed a slightly positive skewness. Exploratory factor analysis proposed a six-factor model. Results for 16 of the 20 items of the Japanese version of the iGLAS-GK were comparable to those from previous studies in other populations. These results indicate that the Japanese version is reliable and can be used to measure the genomic knowledge of adults in the general population, and this version of the knowledge measure maintains the multidimensional structure for assessing genomic knowledge.

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Funding: This research was funded by the Tohoku Medical Megabank Project from the Japan Agency for Medical Research and Development (JP21tm0124006).

Data Access Statement:

Data Availability Statement: The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.


genetics; genomic knowledge; international genetics literacy and attitudes survey; Japanese

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22 March 2023Accepted
28 March 2023Published

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Date Deposited:

28 Mar 2023 15:46

Last Modified:

28 Mar 2023 15:46

Peer Reviewed:

Yes, this version has been peer-reviewed.



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