The development of mental state attributions in women with X-monosomy, and the role of monoamine oxidase B in the sociocognitive phenotype

Lawrence, K.; Jones, Alice P.; Oreland, L.; Spektor, D.; Mandy, W.; Campbell, R. and Skuse, David. 2007. The development of mental state attributions in women with X-monosomy, and the role of monoamine oxidase B in the sociocognitive phenotype. Cognition, 102(1), pp. 84-100. ISSN 00100277 [Article]

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Abstract or Description

We hypothesized that women with Turner syndrome (45,X) with a single X-chromosome inherited from their mother may show mentalizing deficits compared to women of normal karyotype with two X-chromosomes (46,X). Simple geometrical animation events (two triangles moving with apparent intention in relation to each other) which usually elicit mental-state descriptions in normally developing people, did not do so to the same extent in women with Turner syndrome. We then investigated the potential role in this deficit played by monoamine oxidase B enzymatic activity. MAO-B activity reflects central serotonergic activity, and by implication the functional integrity of neural circuits implicated in mentalizing. Platelet MAO-B was substantially reduced in Turner syndrome. However, contrary to prediction, in this (relatively small) sample there was no association between MAO-B enzymatic activity and mentalizing skills in participants with and without Turner syndrome.

Item Type:

Article

Identification Number (DOI):

https://doi.org/10.1016/j.cognition.2005.12.003

Departments, Centres and Research Units:

Psychology

Dates:

DateEvent
2007Published

Item ID:

5336

Date Deposited:

21 Mar 2011 14:30

Last Modified:

04 Jul 2017 09:15

Peer Reviewed:

Yes, this version has been peer-reviewed.

URI:

http://research.gold.ac.uk/id/eprint/5336

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