Gene-environment interaction analysis of serotonin system markers with adolescent depression.

Eley, Thalia C.; Sugden, K.; Corsico, A.; Gregory, Alice M.; Sham, Pak; Plomin, R. and Craig, I. W.. 2004. Gene-environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry, 9, pp. 908-915. [Article]

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Abstract or Description

Winner of the Lilly-Molecular Psychiatry Award

We report analyses from a study of gene-environment interaction in adolescent depression. The sample was selected from 1990 adolescents aged 10-20 years: those with depression symptoms in the top or bottom 15% were identified and divided into high or low environmental risk groups. DNA was obtained from 377 adolescents, representing the four quadrants of high or low depression and high or low environmental risk. Markers within, or close to, each of the serotonergic genes 5HTT, HTR2A, HTR2C, MAOA (monoamine oxidase type A) and tryptophan hydroxylase (TPH) were genotyped. Environmental risk group was a nonsignificant predictor and sex was a significant predictor of the depression group. HTR2A and TPH significantly predicted the depression group, independent of the effects of sex, environmental risk group and their interaction. In addition, there was a trend for an effect of 5HTTLPR, which was significant in female subjects. Furthermore, there was a significant genotype-environmental risk interaction for 5HTTLPR in female subjects only, with the effect being in the same direction as another recent study, reaffirming that an important source of genetic heterogeneity is exposure to environmental risk.

Item Type:

Article

Departments, Centres and Research Units:

Psychology

Dates:

DateEvent
2004Published

Item ID:

7290

Date Deposited:

05 Oct 2012 14:51

Last Modified:

30 Jun 2017 15:19

Peer Reviewed:

Yes, this version has been peer-reviewed.

URI:

http://research.gold.ac.uk/id/eprint/7290

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