Kamin blocking is not disrupted by amphetamine in human subjects

Gray, NS; Pickering, Alan; Gray, JA; Jones, Steven H; Abrahams, S and Hemsley, DR. 1997. Kamin blocking is not disrupted by amphetamine in human subjects. Journal of Psychopharmacology, 11(4), pp. 301-311. ISSN 0269-8811 [Article]

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Abstract or Description

The effect of oral amphetamine administration on the Kamin-blocking effect in healthy volunteer subjects was investigated. Against predictions, Kamin blocking was not disrupted by either a high or low oral dose of D-amphetamine under conditions which have, in previous studies, led to disruption of a related learning phenomenon (latent inhibition). This lack of effect of amphetamine administration upon Kamin blocking weakens hypotheses that this cognitive process is mediated by the same changes in dopaminergic activity which affect latent inhibition. Currently, the only data which show strong comparative associations between Kamin blocking and latent inhibition are when they are applied to schizophrenic populations. These results may suggest that Kamin blocking and latent inhibition may be measuring different aspects of schizophrenic cognitive dysfunction.

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amphetamine, Kamin-blocking effect, schizophrenia

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July 1997Published

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Date Deposited:

20 Mar 2015 11:14

Last Modified:

04 Jul 2017 10:31

Peer Reviewed:

Yes, this version has been peer-reviewed.



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