Error signals in the subthalamic nucleus are related to post-error slowing in patients with Parkinson's disease

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Siegert, Sandy; Herrojo Ruiz, Maria; Brücke, Christof; Huebl, Julius; Schneider, Gerd-Helge; Ullsperger, Markus and Kühn, Andrea A.. 2014. Error signals in the subthalamic nucleus are related to post-error slowing in patients with Parkinson's disease. Cortex, 60, pp. 103-120. ISSN 0010-9452 [Article]

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Official URL: http://doi.org/10.1016/j.cortex.2013.12.008

Abstract or Description

Error monitoring is essential for optimizing motor behavior. It has been linked to the medial frontal cortex, in particular to the anterior midcingulate cortex (aMCC). The aMCC subserves its performance-monitoring function in interaction with the basal ganglia (BG) circuits, as has been demonstrated in patients suffering from BG lesions or from Parkinson's disease (PD). The subthalamic nucleus (STN) has been assumed an integrative structure for emotional, cognitive and motor processing. Error-related behavioral adaptation such as post-error slowing has been linked to motor inhibition involving activation of an inhibitory network including the STN. However, direct involvement of the STN in error monitoring and post-error behavioral adjustment has not yet been demonstrated.

Here, we used simultaneous scalp electroencephalogram (EEG) and local field potential (LFP) recordings from the BG in 17 patients undergoing deep brain stimulation (DBS) for PD to investigate error-related evoked activity in the human STN, its relation to post-error behavioral adjustment and the influence of dopamine during the performance of a speeded flanker task.

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Article

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https://doi.org/10.1016/j.cortex.2013.12.008