Smith, D. M. and Terhune, Devin Blair. 2023. Pedunculopontine-Induced cortical decoupling as the neurophysiological locus of dissociation. Psychological Review, 130(1), pp. 183-210. ISSN 0033-295X [Article]

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Abstract or Description

Mounting evidence suggests an association between aberrant sleep phenomena and dissociative experiences. However, no wake-sleep boundary theory provides a compelling explanation of dissociation or specifies its physiological substrates. We present a theoretical account of dissociation that integrates theories and empirical results from multiple lines of research concerning the domain of dissociation and the regulation of rapid eye movement (REM) sleep.
This theory posits that individual differences in the circuitry governing the REM sleep promoting Pedunculopontine Nucleus and Laterodorsal Tegmental Nucleus determine the degree of similarity in the cortical connectivity profiles of wakefulness and REM sleep. We propose that a latent trait characterized by elevated dissociative experiences emerges from the decoupling of frontal executive regions due to a REM sleep-like aminergic/cholinergic balance. The
Pedunculopontine Induced Cortical Decoupling Account of Dissociation (PICDAD) suggests multiple fruitful lines of inquiry and provides novel insights.

Item Type:	Article
Identification Number (DOI):	https://doi.org/10.1037/rev0000353
Additional Information:	©American Psychological Association, 2021. This paper is not the copy of record and may not exactly replicate the authoritative document published in the APA journal. The final article is available, upon publication, at Psychological Review.”
Keywords:	Dissociation, Suggestibility, REM Sleep, Pedunculopontine Nucleus, Functional Connectivity
Departments, Centres and Research Units:	Psychology
Dates:	Date Event 12 December 2021 Accepted 27 January 2022 Published Online 2023 Published
Item ID:	30968
Date Deposited:	05 Jan 2022 10:29
Last Modified:	15 Feb 2023 10:49
Peer Reviewed:	Yes, this version has been peer-reviewed.
URI:	https://research.gold.ac.uk/id/eprint/30968

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