Madrid-Valero, J.J.; Rijsdijk, Fruhling; Selzam, Saskia; Zavos, Helena M. S.; Schneider, Melanie; Ronald, Angelica and Gregory, Alice M.. 2023. Sub-types of insomnia in adolescents: insights from a quantitative/molecular twin study. JCPP Advances, 3(2), ISSN 2692-9384 [Article]

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Abstract or Description

Background: Insomnia with short sleep duration has been postulated as more severe than that accompanied by normal/long sleep length. While the short duration subtype is considered to have greater genetic influence than the other subtype, no studies have addressed this question. This study aimed to compare these subtypes in terms of: 1) the heritability of insomnia symptoms; 2) polygenic scores (PGS) for insomnia symptoms and sleep duration; 3) the associations between insomnia symptoms and a wide variety of traits/disorders.

Methods: The sample comprised 4,000 pairs of twins aged 16 from the Twins Early Development Study. Twin models were fitted to estimate the heritability of insomnia in both groups. PGS were calculated for self-reported insomnia and sleep duration and compared among participants with short and normal/long sleep duration.

Results: Heritability was not significantly different in the short sleep duration group (A=0.13 [95%CI=0.01, 0.32]) and the normal/long sleep duration group (A=0.35 [95%CI=0.29, 0.40]). Shared environmental factors accounted for a substantial proportion of the variance in the short sleep duration group (C=0.19 [95%CI= 0.05, 0.32]) but not in the normal/long sleep duration group (C=0.00 [95%CI=0.00, 0.04]). PGS did not differ significantly between groups although results were in the direction expected by the theory. Our results also showed that insomnia with short (as compared to normal/long) sleep duration had a stronger association with anxiety and depression (p<.05) - although not once adjusting for multiple testing.

Conclusions: We found mixed results in relation to the expected differences between the insomnia subtypes in adolescents. Future research needs to further establish cut-offs for ‘short’ sleep at different developmental stages and employ objective measures of sleep.

Item Type:	Article
Identification Number (DOI):	https://doi.org/10.1002/jcv2.12167
Additional Information:	Funding information: Medical Research Council. Grant Numbers: G1100559, MR/V012878/1, MR/M021475/1; National Institutes of Health. Grant Number: AG046938
Data Access Statement:	Data availability statement: Under restrictions. Juan J. Madrid‐Valero had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Keywords:	Heritability, Insomnia, Polygenic Scores, Sleep duration, Sub-types, Twins.
Departments, Centres and Research Units:	Psychology
Dates:	Date Event 31 March 2023 Accepted 6 May 2023 Published Online
Item ID:	33336
Date Deposited:	05 Apr 2023 10:29
Last Modified:	17 Jun 2024 15:15
Peer Reviewed:	Yes, this version has been peer-reviewed.
URI:	https://research.gold.ac.uk/id/eprint/33336

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