Domain-Specific Working Memory, But Not Dopamine-Related Genetic Variability, Shapes Reward-Based Motor Learning

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Holland, Peter; Codol, Olivier; Oxley, Elizabeth; Taylor, Madison; Hamshere, Elizabeth; Joseph, Shadiq; Huffer, Laura and Galea, Joseph M.. 2019. Domain-Specific Working Memory, But Not Dopamine-Related Genetic Variability, Shapes Reward-Based Motor Learning. Journal of Neuroscience, 39(47), pp. 9383-9396. ISSN 0270-6474 [Article]

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Official URL: https://doi.org/10.1523/JNEUROSCI.0583-19.2019

Abstract or Description

The addition of rewarding feedback to motor learning tasks has been shown to increase the retention of learning, spurring interest in its possible utility for rehabilitation. However, motor tasks using rewarding feedback have repeatedly been shown to lead to great interindividual variability in performance. Understanding the causes of such variability is vital for maximizing the potential benefits of reward-based motor learning. Thus, using a large human cohort of both sexes (n = 241), we examined whether spatial (SWM), verbal, and mental rotation (RWM) working memory capacity and dopamine-related genetic profiles were associated with performance in two reward-based motor tasks. The first task assessed the participant's ability to follow a slowly shifting reward region based on hit/miss (binary) feedback. The second task investigated the participant's capacity to preserve performance with binary feedback after adapting to the rotation with full visual feedback. Our results demonstrate that higher SWM is associated with greater success and an enhanced capacity to reproduce a successful motor action, measured as change in reach angle following reward. In contrast, higher RWM was predictive of an increased propensity to express an explicit strategy when required to make large reach angle adjustments. Therefore, SWM and RWM were reliable, but dissociable, predictors of success during reward-based motor learning. Change in reach direction following failure was also a strong predictor of success rate, although we observed no consistent relationship with working memory. Surprisingly, no dopamine-related genotypes predicted performance. Therefore, working memory capacity plays a pivotal role in determining individual ability in reward-based motor learning.

Item Type:

Article

Identification Number (DOI):

https://doi.org/10.1523/JNEUROSCI.0583-19.2019

Additional Information:

This work was supported by the European Research Council Starting Grant MotMotLearn 637488.

Keywords:

genetics; motor learning; reaching; reward; working memory

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