Musical rhythm abilities and risk for developmental speech-language problems and disorders: epidemiological and polygenic associations

Tools

Nayak, Srishti; Ladanyi, Eniko; Eising, Else; Mekki, Yasmina; Nitin, Rachana; Bush, Catherine T; Gustavson, Daniel E; Anglada-Tort, Manuel; Lancaster, Hope S; Mosing, Miriam A; Ullén, Fredrik; Magne, Cyrille L.; Fisher, Simon E.; Jacoby, Nori and Gordon, Reyna L.. 2024. Musical rhythm abilities and risk for developmental speech-language problems and disorders: epidemiological and polygenic associations. PsyArXiv Preprint, [Article] (Submitted)

Preview

Text
Nayak_et al_RhythmandSpeechLanguageProblemsandDisorders_preprint.pdf - Submitted Version
Available under License Creative Commons Attribution.
Download (654kB) | Preview

Official URL: https://osf.io/preprints/psyarxiv/kcgp5_v1

Abstract or Description

Impaired musical rhythm abilities and developmental speech-language related disorders are biologically and clinically intertwined. Prior work examining their relationship has primarily used small samples; here, we studied associations at population-scale by conducting the largest systematic epidemiological investigation to date (total N = 39,092). Based on existing theoretical frameworks, we predicted that rhythm impairment would be a significant risk factor for speech-language disorders in the general adult population. Findings were consistent across multiple independent datasets and rhythm subskills (including beat synchronization and rhythm discrimination), and aggregate meta-analyzed data showed that rhythm impairment is a modest but consistent risk factor for developmental speech, language, and reading disorders (OR = 1.32 [1.14 – 1.49]; p < .0001). Further, cross-trait polygenic score analyses indicate shared genetic architecture between musical rhythm and reading abilities, providing evidence for genetic pleiotropy between rhythm and language-related phenotypes.

Item Type:

Article

Identification Number (DOI):

https://doi.org/10.31234/osf.io/kcgp5