Dodd, James W; Chung, Ai Wern; van den Broek, Martin D; Barrick, Thomas R; Charlton, Rebecca A and Jones, Paul W. 2012. Brain structure and function in chronic obstructive pulmonary disease: a multimodal cranial magnetic resonance imaging study. American journal of respiratory and critical care medicine, 186(3), pp. 240-5. ISSN 1535-4970 [Article]

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Abstract or Description

In stable nonhypoxemic COPD there is reduced white matter integrity throughout the brain and widespread disturbance in functional activation of gray matter, which may contribute to cognitive dysfunction. White matter microstructural integrity but not gray matter functional activation is independent of smoking and cerebrovascular comorbidity. The mechanisms remain unclear, but may include cerebral small vessel disease caused by COPD.

Item Type:	Article
Departments, Centres and Research Units:	Psychology
Dates:	Date Event 1 August 2012 Published
Item ID:	8313
Date Deposited:	09 Jun 2013 12:43
Last Modified:	30 Jun 2017 14:11
Peer Reviewed:	Yes, this version has been peer-reviewed.
URI:	https://research.gold.ac.uk/id/eprint/8313

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