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Disorder-specific and shared neurophysiological impairments of attention and inhibition in women with attention-deficit/hyperactivity disorder and women with bipolar disorder

Michelini, G; Kitsune, G; Hosang, Georgina M.; Asherson, Philip; McLoughlin, G and Kuntsi, J. 2015. Disorder-specific and shared neurophysiological impairments of attention and inhibition in women with attention-deficit/hyperactivity disorder and women with bipolar disorder. Psychological Medicine, 46(3), pp. 493-504. ISSN 0033-2917 [Article]

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Abstract or Description

Background. In adults, attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) have certain overlap- ping symptoms, which can lead to uncertainty regarding the boundaries of the two disorders. Despite evidence of cog- nitive impairments in both disorders separately, such as in attentional and inhibitory processes, data on direct comparisons across ADHD and BD on cognitive–neurophysiological measures are as yet limited.
Method. We directly compared cognitive performance and event-related potential measures from a cued continuous performance test in 20 women with ADHD, 20 women with BD (currently euthymic) and 20 control women.
Results. The NoGo-N2 was attenuated in women with BD, reflecting reduced conflict monitoring, compared with women with ADHD and controls (both p < 0.05). Both ADHD and BD groups showed a reduced NoGo-P3, reflecting inhibitory control, compared with controls (both p < 0.05). In addition, the contingent negative variation was significantly reduced in the ADHD group (p = 0.05), with a trend in the BD group (p = 0.07), compared with controls.
Conclusions. These findings indicate potential disorder-specific (conflict monitoring) and overlapping (inhibitory con- trol, and potentially response preparation) neurophysiological impairments in women with ADHD and women with BD. The identified neurophysiological parameters further our understanding of neurophysiological impairments in women with ADHD and BD, and are candidate biomarkers that may aid in the identification of the diagnostic boundaries of the two disorders.

Item Type:

Article

Identification Number (DOI):

https://doi.org/10.1017/S0033291715001877

Keywords:

Attention; attention-deficit/hyperactivity disorder; bipolar disorder; conflict monitoring; event-related potentials; inhibitory control

Departments, Centres and Research Units:

Psychology

Dates:

DateEvent
10 November 2015Published

Item ID:

17035

Date Deposited:

16 Mar 2016 13:24

Last Modified:

11 Jul 2018 17:59

Peer Reviewed:

Yes, this version has been peer-reviewed.

URI:

http://research.gold.ac.uk/id/eprint/17035

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