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Goldsmiths - University of London

GABA Predicts Time Perception

Terhune, Devin Blair; Russo, S.; Near, J.; Stagg, C. J. and Cohen Kadosh, R.. 2014. GABA Predicts Time Perception. Journal of Neuroscience, 34(12), pp. 4364-4370. ISSN 0270-6474 [Article]

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Abstract or Description

Our perception of time constrains our experience of the world and exerts a pivotal influence over a myriad array of cognitive and motor functions. There is emerging evidence that the perceived duration of subsecond intervals is driven by sensory-specific neural activity in human and nonhuman animals, but the mechanisms underlying individual differences in time perception remain elusive. We tested the hypothesis that elevated visual cortex GABA impairs the coding of particular visual stimuli, resulting in a dampening of visual processing and concomitant positive time-order error (relative underestimation) in the perceived duration of subsecond visual intervals. Participants completed psychophysical tasks measuring visual interval discrimination and temporal reproduction and we measured in vivo resting state GABA in visual cortex using magnetic resonance spectroscopy. Time-order error selectively correlated with GABA concentrations in visual cortex, with elevated GABA associated with a rightward horizontal shift in psychometric functions, reflecting a positive time-order error (relative underestimation). These results demonstrate anatomical, neurochemical, and task specificity and suggest that visual cortex GABA contributes to individual differences in time perception.

Item Type: Article

Identification Number (DOI):

10.1523/JNEUROSCI.3972-13.2014

Departments, Centres and Research Units:

Psychology

Dates:

DateEvent
February 2014UNSPECIFIED

Item ID:

17053

Date Deposited:

30 Mar 2016 09:38

Last Modified:

28 Feb 2017 17:16

URI: http://research.gold.ac.uk/id/eprint/17053

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