Research Online

Logo

Goldsmiths - University of London

Stressful life events and Catechol-O-methyl-transferase (COMT) gene in bipolar disorder

Hosang, Georgina M.; Fisher, Helen L.; Cohen-Woods, Sarah; McGuffin, Peter and Farmer, Anne E.. 2017. Stressful life events and Catechol-O-methyl-transferase (COMT) gene in bipolar disorder. Depression and Anxiety, 34, pp. 419-426. ISSN 1091-4269 [Article]

[img] Text
Corrected_Hosang et al_final.docx - Accepted Version
Available under License Creative Commons Attribution No Derivatives.

Download (119kB)
[img]
Preview
Image
Final_Figure 1_TIFF.tiff - Supplemental Material
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (485kB) | Preview

Abstract or Description

Background: A small body of research suggests that gene-environment interactions play an important role in the development of bipolar disorder. The aim of the present study is to contribute to this work by exploring the relationship between stressful life events and the COMT Val158Met polymorphism in bipolar disorder. Methods: A total of 482 bipolar cases and 205 psychiatrically healthy controls completed the List of Threatening Experiences Questionnaire. Bipolar cases reported the events experienced 6 months before their worst depressive and manic episodes; controls reported those events experienced 6 months prior to their interview. The genotypic information for the COMT Val158Met variant (rs4680) was extracted from GWAS analysis of the sample. Results: The impact of stressful life events was moderated by the COMT genotype for the worst depressive episode using a Val dominant model (adjusted Risk Difference = 0.09, 95% confidence intervals 0.003-0.18, p=0.04). For the worst manic episodes no significant interactions between COMT and stressful life events were detected. Conclusions: This is the first study to explore the relationship between stressful life events and the COMT Val158Met polymorphism focusing solely on bipolar disorder. The results of this study highlight the importance of the interplay between genetic and environmental factors for bipolar depression.

Item Type:

Article

Identification Number (DOI):

https://doi.org/10.1002/da.22606

Keywords:

bipolar disorder; COMT; depression; gene–environment interaction; life stress; stressful life events

Departments, Centres and Research Units:

Psychology

Dates:

DateEvent
19 January 2017Published Online
22 December 2016Accepted

Item ID:

19460

Date Deposited:

17 Jan 2017 13:51

Last Modified:

23 Jan 2018 11:51

Peer Reviewed:

Yes, this version has been peer-reviewed.

URI:

http://research.gold.ac.uk/id/eprint/19460

View statistics for this item...

Edit Record Edit Record (login required)