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Chronic schizophrenics with positive symptomatology have shortened EEG microstate durations

Strelets, V.; Faber, P. L.; Golikova, J.; Novototsky-Vlasov, V.; Koenig, T.; Gianotti, L. R. R.; Gruzelier, John and Lehmann, Dietrich. 2003. Chronic schizophrenics with positive symptomatology have shortened EEG microstate durations. Clinical Neurophysiology, 114(11), pp. 2043-2051. ISSN 13882457 [Article]

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Abstract or Description

Objective: In young, first-episode, never-treated schizophrenics compared with controls, (a) generally shorter durations of EEG microstates were reported (Koukkou et al., Brain Topogr 6 (1994) 251; Kinoshita et al., Psychiatry Res Neuroimaging 83 (1998) 58), and (b) specifically, shorter duration of a particular class of microstates (Koenig et al., Eur Arch Psychiatry Clin Neurosci 249 (1999) 205). We now examined whether older, chronic schizophrenic patients with positive symptomatology also show these characteristics.

Methods: Multichannel resting EEG (62.2 s/subject) from two subject groups, 14 patients (36.1±10.2 years old) and 13 controls (35.1±8.2 years old), all males, was analyzed into microstates using a global approach for microstate analysis that clustered the microstates into 4 classes (Koenig et al., 1999).

Results: (a) Hypothesis testing of general microstate shortening supported a trend (P=0.064). (b) Two-way repeated measure ANOVA (two subject groups×4 microstate classes) showed a significant group effect for microstate duration. Posthoc tests revealed that a microstate class with brain electric field orientation from left central to right central-posterior had significantly shorter microstates in patients than controls (68.5 vs. 76.1 ms, P=0.034).

Conclusions: The results were in line with the results from young, never-treated, productive patients, thus suggesting that in schizophrenic information processing, one class of mental operations might intermittently cause deviant mental constructs because of premature termination of processing.

Item Type:

Article

Identification Number (DOI):

https://doi.org/10.1016/S1388-2457(03)00211-6

Departments, Centres and Research Units:

Psychology

Dates:

DateEvent
2003Published

Item ID:

5253

Date Deposited:

16 Mar 2011 10:00

Last Modified:

30 Jun 2017 15:27

Peer Reviewed:

Yes, this version has been peer-reviewed.

URI:

http://research.gold.ac.uk/id/eprint/5253

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