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Lack of cognitive recovery following withdrawal from long-term benzodiazepine use

Tata, Philip R; Rollings, J; Collins, M; Pickering, Alan and Jacobson, RR. 1994. Lack of cognitive recovery following withdrawal from long-term benzodiazepine use. Psychological Medicine, 24(01), pp. 203-213. ISSN 0033-2917 [Article]

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Abstract or Description

Twenty-one patients with significant long-term therapeutic benzodiazepine (BZ) use, who remained abstinent at 6 months follow-up after successfully completing a standardized inpatient BZ withdrawal regime, and 21 normal controls matched for age and IQ but not for anxiety, were repeatedly tested on a simple battery of routine psychometric tests of cognitive function, pre- and post-withdrawal and at 6 months follow-up. The results demonstrated significant impairment in patients in verbal learning and memory, psychomotor, visuo-motor and visuo-conceptual abilities, compared with controls, at all three time points. Despite practice effects, no evidence of immediate recovery of cognitive function following BZ withdrawal was found. Modest recovery of certain deficits emerged at 6 months follow-up in the BZ group, but this remained significantly below the equivalent control performance. The implications of persisting cognitive deficits after withdrawal from long-term BZ use are discussed.

Item Type:

Article

Identification Number (DOI):

https://doi.org/10.1017/S0033291700026969

Departments, Centres and Research Units:

Psychology

Dates:

DateEvent
February 1994Published

Item ID:

8446

Date Deposited:

20 Mar 2015 14:20

Last Modified:

04 Jul 2017 10:31

Peer Reviewed:

Yes, this version has been peer-reviewed.

URI:

http://research.gold.ac.uk/id/eprint/8446

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