CSynth: An Interactive Modelling and Visualisation Tool for 3D Chromatin Structure

Todd, Stephen; Todd, Peter; McGowan, Simon J; Hughes, James R; Kakui, Yasutaka; Fol Leymarie, Frederic; Latham, William; Taylor, Stephen and Valencia, Alfonso. 2020. CSynth: An Interactive Modelling and Visualisation Tool for 3D Chromatin Structure. Bioinformatics, ISSN 1367-4803 [Article] (In Press)

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Abstract or Description

Motivation
The 3D structure of chromatin in the nucleus is important for gene expression and regulation. Chromosome conformation capture techniques, such as Hi-C, generate large amounts of data showing interaction points on the genome but these are hard to interpret using standard tools.

Results
We have developed CSynth, an interactive 3D genome browser and real-time chromatin restraint-based modeller to visualise models of any chromosome conformation capture (3C) data. Unlike other modelling systems CSynth allows dynamic interaction with the modelling parameters to allow experimentation and effects on the model. It also allows comparison of models generated from data in different tissues / cell states and the results of third-party 3D modelling outputs. In addition, we include an option to view and manipulate these complicated structures using Virtual Reality (VR) so scientists can immerse themselves in the models for further understanding. This VR component has also proven to be a valuable teaching and public engagement tool.

Availability
CSynth is web based and available to use at https://csynth.org.

Item Type:

Article

Identification Number (DOI):

https://doi.org/10.1093/bioinformatics/btaa757

Additional Information:

Supplementary information
Supplementary data are available at Bioinformatics online.

Funding: Medical Research Council (MC_UU_12025) and Wellcome Trust (106130/Z/14/B).

Departments, Centres and Research Units:

Computing

Dates:

DateEvent
19 August 2020Accepted
31 August 2020Published Online

Item ID:

29368

Date Deposited:

26 Oct 2020 09:10

Last Modified:

26 Oct 2020 11:47

Peer Reviewed:

Yes, this version has been peer-reviewed.

URI:

https://research.gold.ac.uk/id/eprint/29368

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